A Perspective on Neuronal Cell Death Signaling and Neurodegeneration
نویسندگان
چکیده
منابع مشابه
Calcium and cell death signaling in neurodegeneration and aging.
Transient increase in cytosolic (Cac2+) and mitochondrial Ca2+ (Ca m2+) are essential elements in the control of many physiological processes. However, sustained increases in Ca c2+ and Ca m2+ may contribute to oxidative stress and cell death. Several events are related to the increase in Ca m2+, including regulation and activation of a number of Ca2+ dependent enzymes, such as phospholipases, ...
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The protein kinase mammalian Sterile 20-like kinase 1 (MST1) plays a critical role in the regulation of cell death. Recent studies suggest that MST1 mediates oxidative stress-induced neuronal cell death by phosphorylating the transcription factor FOXO3 at serine 207, a site that is conserved in other FOXO family members. Here, we show that MST1-induced phosphorylation of FOXO1 at serine 212, co...
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ژورنال
عنوان ژورنال: Molecular Neurobiology
سال: 2010
ISSN: 0893-7648,1559-1182
DOI: 10.1007/s12035-010-8128-2